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A yeast strain with a mutant spo11— allele (the mutant allele is nonfunctional; it makes no Spoil protein) has been isolated. What do you suppose is the phenotype of this mutant strain?

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Answer:

The protein Spo11 performs an essential function in starting the process of recombination. If yeast exhibits a mutation on spo11- allele, it turns non-functional and it cannot generate the protein spo11 anymore. As a consequence, it cannot go through any recombination process, and the spores generated from it would be inviable because of aneuploidy. Aneuploidy refers to a condition in which the cell comprises an unusual number of chromosomes.